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Related Concept Videos

Bone Markings

Bone Markings

Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

The Bone Matrix

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Video

Updated: Jun 25, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Bone markers--new aspects.

Serge Cremers¹, John P Bilezikian, Patrick Garnero

¹Department of Medicine, Endocrinology, Columbia University, New York, NY 10032, USA. SC2752@Columbia.edu

Clinical Laboratory

|February 17, 2009

Summary

This summary is machine-generated.

Bone turnover markers in serum and urine aid in assessing bone remodeling. Recent advancements include new markers, assays, automation, quality control, and statistical analysis for better clinical application.

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Last Updated: Jun 25, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

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Published on: September 27, 2024

Area of Science:

Biochemistry
Orthopedics
Clinical Chemistry

Background:

Bone turnover markers (BTMs) are crucial for evaluating bone remodeling.
Current BTMs are measured in serum and urine.
Understanding BTMs aids in diagnosing and managing bone diseases.

Purpose of the Study:

To review recent advancements in bone turnover marker technology.
To discuss the clinical utility of new developments in BTMs.
To highlight improved data interpretation methods for BTMs.

Main Methods:

Review of literature on novel bone turnover markers.
Discussion of new analytical assay development and automation.
Exploration of quality assurance programs and statistical modeling for BTM data.

Main Results:

Newer bone turnover markers are now available.
Analytical assays for BTMs have been improved and automated.
Enhanced data interpretation using statistical models is feasible.

Conclusions:

Advancements in BTMs offer improved diagnostic and monitoring capabilities.
New technologies enhance the reliability and application of BTMs in clinical practice.
Sophisticated data analysis improves the clinical utility of BTMs for patient care.