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Related Concept Videos

Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
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Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...

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Related Experiment Video

Updated: Jun 25, 2026

Nasal Wipes for Influenza A Virus Detection and Isolation from Swine
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Nasal Wipes for Influenza A Virus Detection and Isolation from Swine

Published on: December 4, 2015

African swine fever virus.

E R Tulman1, G A Delhon, B K Ku

  • 1Department of Pathobiology and Veterinary Science, Center of Excellence for Vaccine Research, University of Connecticut, Storrs 06269, USA. edan.tulman@uconn.edu

Current Topics in Microbiology and Immunology
|February 17, 2009
PubMed
Summary

African swine fever virus (ASFV) causes a lethal disease in pigs. Research reveals ASFV

Area of Science:

  • Virology
  • Molecular Biology
  • Immunology

Background:

  • African swine fever virus (ASFV) is a unique DNA arbovirus, the only member of the Asfarviridae family.
  • ASFV causes a severe hemorrhagic disease in domestic swine, making it a critical subject of study.
  • Understanding ASFV's replication and host interactions is vital for disease control.

Purpose of the Study:

  • To elucidate the complex mechanisms of ASFV replication within host cells.
  • To investigate ASFV's intricate interactions with the host immune system.
  • To identify novel viral genes influencing ASFV virulence and transmission.

Main Methods:

  • Analysis of ASFV's intracytoplasmic replication cycle.
  • Investigation of virus-host cell interactions at the molecular level.

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  • Genomic and functional studies of ASFV genes.

    • Main Results:

    • ASFV exhibits complex replication strategies within host cells.
    • Novel ASFV genes were identified that modulate host immune responses.
    • These genes also play roles in ASFV virulence and its spread in tick vectors.

    Conclusions:

    • ASFV's unique genetic makeup drives complex host-pathogen interactions.
    • ASFV research broadens the understanding of DNA virus replication and host immune evasion.
    • Findings contribute to strategies for managing African swine fever.