Marfan syndrome-an orthodontic perspective

Area of Science:

• Genetics and Hereditary Diseases
• Dental and Oral Health
• Connective Tissue Disorders

Background:

• Marfan syndrome is an autosomal dominant inherited connective tissue disorder affecting multiple organ systems.
• Key features include skeletal, ocular, and cardiovascular manifestations, alongside characteristic orofacial traits like high-arched palate and Class II malocclusion.
• Diagnosis in individuals without a family history requires involvement of at least three body systems.

Observation:

• This report details the orthodontic treatment of three patients diagnosed with Marfan syndrome.
• Two patients exhibited severe periodontal disease without apparent local etiological factors.
• Clinical presentations and systemic involvement varied significantly among the patients, impacting timely diagnosis.

Findings:

• Intraoral findings in Marfan syndrome patients can include severe periodontal disease and specific malocclusions.
• The diverse presentation of Marfan syndrome necessitates a high index of suspicion in dental settings.
• Orthodontic management requires careful consideration of the syndrome's systemic implications.

Implications:

• Early recognition of orofacial manifestations can aid in the diagnosis of Marfan syndrome.
• Dental professionals play a crucial role in identifying potential Marfan syndrome cases.
• Tailored orthodontic approaches are essential for effectively treating patients with Marfan syndrome.