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Updated: Jun 25, 2026
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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
D-amino acid oxidase: physiological role and applications
S V Khoronenkova1, V I Tishkov
1Chemistry Faculty, Lomonosov Moscow State University, Moscow, 119992, Russia.
Biochemistry. Biokhimiia
|February 17, 2009
Summary
D-amino acids are vital for cell regulation. FAD-dependent D-amino acid oxidase (DAAO) enzyme activity impacts nervous system and hormone functions, with implications for disease and potential diagnostic/therapeutic uses.
Area of Science:
- Biochemistry
- Cell Biology
- Neuroscience
Background:
- D-amino acids are crucial regulators of cellular processes.
- FAD-dependent D-amino acid oxidase (DAAO) maintains D-amino acid homeostasis.
- Dysregulation of D-amino acid levels is linked to various diseases.
Purpose of the Study:
- To review the regulatory roles of D-amino acids in biological systems.
- To highlight the significance of DAAO in maintaining D-amino acid balance.
- To explore the implications of altered DAAO activity on physiological and pathological processes.
Main Methods:
- Literature review of studies on D-amino acid metabolism.
- Analysis of the enzymatic activity and regulation of DAAO.
- Examination of the link between D-amino acids, DAAO, and disease pathogenesis.
Main Results:
- DAAO influences multiple D-amino acid levels, leading to complex regulatory effects.
- Altered DAAO activity is associated with nervous system function and hormone secretion.
- The enzyme's role in disease development and its potential for diagnostic and therapeutic applications are discussed.
Conclusions:
- DAAO is a key enzyme with multifaceted roles in cellular regulation.
- Understanding DAAO's complex mechanisms is vital for addressing related diseases.
- DAAO presents opportunities for future diagnostic and therapeutic strategies.
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