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Related Experiment Video

Updated: Jun 25, 2026

Diffusion Imaging in the Rat Cervical Spinal Cord
10:46

Diffusion Imaging in the Rat Cervical Spinal Cord

Published on: April 7, 2015

Diffusion tensor imaging of cocaine-treated rodents.

Ponnada A Narayana1, Pallavi Ahobila-Vajjula, Jaivijay Ramu

  • 1Diagnostic and Interventional Imaging, University of Texas Medical School at Houston, Houston, TX 77030, USA. ponnada.a.narayana@uth.tmc.edu

Psychiatry Research
|February 17, 2009
PubMed
Summary

Chronic cocaine use in rats significantly decreased white matter integrity in the corpus callosum (CC), indicated by reduced fractional anisotropy (FA) and altered neurofilament and myelin levels.

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Area of Science:

  • Neuroscience
  • Toxicology
  • Neuroimaging

Background:

  • Diffusion tensor imaging (DTI) studies reveal white matter abnormalities in cocaine-dependent humans.
  • It remains unclear if these DTI-observed fractional anisotropy (FA) differences stem from pre-existing traits or cocaine's effects.

Purpose of the Study:

  • To investigate the direct impact of chronic cocaine administration on white matter integrity.
  • To examine histological changes in the brain's white matter following sustained cocaine exposure.

Main Methods:

  • 24 rats received continuous cocaine or saline infusion for 4 weeks.
  • Diffusion tensor imaging (DTI) was conducted, followed by brain histology.
  • Voxel-based morphometry analyzed FA changes, and histological markers (neurofilament, myelin basic protein) were quantified.

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Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

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Related Experiment Videos

Last Updated: Jun 25, 2026

Diffusion Imaging in the Rat Cervical Spinal Cord
10:46

Diffusion Imaging in the Rat Cervical Spinal Cord

Published on: April 7, 2015

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

Main Results:

  • Cocaine-treated rats showed an 18% decrease in FA in the splenium of the corpus callosum (CC) compared to controls.
  • Histology revealed a 125% increase in neurofilament expression and a 40% decrease in myelin basic protein in the CC splenium of cocaine-exposed rats.
  • Findings suggest chronic cocaine use alters white matter integrity.

Conclusions:

  • This study provides evidence that chronic cocaine abuse directly impacts white matter integrity, specifically in the corpus callosum (CC).
  • Observed species-specific differences in affected brain regions (splenium in rats vs. genu in humans) may be attributed to variations in brain structure, function, or cocaine administration parameters.