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Updated: Jun 25, 2026

Modified In Vivo Matrix Gel Plug Assay for Angiogenesis Studies
Published on: June 30, 2023
Regulation of angiogenesis by oxygen and metabolism
Peter Fraisl1, Massimiliano Mazzone, Thomas Schmidt
1Vesalius Research Center, Leuven, Belgium.
Abstract:
Blood vessels form an important interface between the environment and the organism by carrying oxygen and nutrients to all cells and thus determining cellular metabolism. It is therefore not surprising that oxygen and metabolism influence the development of the vascular network. Here, we discuss recent insights regarding the emerging crosstalk between angiogenesis and metabolism. We will highlight advances in how oxygen and metabolism regulate angiogenesis as well as how angiogenic factors in turn also regulate metabolism.
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