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Related Concept Videos

Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

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Related Experiment Video

Updated: Jun 25, 2026

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
14:26

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

Longitudinal changes in abdominal fat distribution with menopause.

Ruth M Franklin1, Lori Ploutz-Snyder, Jill A Kanaley

  • 1Exercise Science Department, Syracuse University, Syracuse, NY 13244-5040, USA. rmfrankl@syr.edu

Metabolism: Clinical and Experimental
|February 17, 2009
PubMed
Summary
This summary is machine-generated.

Menopause significantly increases total abdominal fat, including visceral and subcutaneous fat, even without changes in body weight or physical activity. However, the relative distribution of this fat between visceral and subcutaneous depots remains unchanged.

Related Experiment Videos

Last Updated: Jun 25, 2026

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
14:26

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

Area of Science:

  • Endocrinology
  • Body Composition Analysis
  • Women's Health

Background:

  • Menopause is associated with increased abdominal fat, but its specific impact on visceral versus subcutaneous fat distribution is not well understood.
  • Understanding these changes is crucial for assessing metabolic and cardiovascular disease risk in aging women.

Purpose of the Study:

  • To investigate the effects of menopause on abdominal fat content (volume) and distribution (visceral vs. subcutaneous).
  • To determine if changes in body weight, waist circumference, or physical activity influence fat accumulation during menopause.

Main Methods:

  • Longitudinal study using magnetic resonance imaging (MRI) to quantify abdominal fat depots.
  • Inclusion of 8 healthy premenopausal women, reassessed 8 years later in the postmenopausal state.
  • Measurement of physical activity, body weight, waist circumference, and blood lipid profiles.

Main Results:

  • Total abdominal fat, visceral fat, and subcutaneous fat significantly increased postmenopause (P < .05).
  • No significant changes were observed in body weight, waist circumference, or physical activity levels.
  • Relative distribution of visceral and subcutaneous fat remained consistent, with no significant difference between premenopausal and postmenopausal states.

Conclusions:

  • Menopause leads to a significant increase in overall abdominal adiposity, particularly visceral and subcutaneous fat, independent of body weight or physical activity.
  • The relative proportion of visceral to subcutaneous abdominal fat does not significantly change with menopause.
  • Further research is warranted to explore the long-term health implications of increased abdominal fat in postmenopausal women.