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Updated: Jun 25, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Continuous improvement process for a high-risk population: catheter-directed thrombolytic infusions
1St Joseph Mercy Hospital, Ann Arbor, Michigan 48103, USA.
Insights
Catheter-directed thrombolysis for ischemic limbs is high-risk. A multidisciplinary team improved care through continuous improvement and concurrent data collection, enhancing safety for this low-volume procedure.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Healthcare Quality Improvement
Background:
- Catheter-directed thrombolysis is crucial for ischemic limb reperfusion but carries significant risks.
- Effective management requires coordinated, multidisciplinary care across all settings.
Purpose of the Study:
- To enhance the safety and efficiency of catheter-directed thrombolysis for peripheral ischemia.
- To implement a continuous improvement process for a high-risk, low-volume procedure.
Main Methods:
- Formation of a multidisciplinary team to analyze and standardize care processes.
- Concurrent data collection over 4 years to identify and resolve problems in real-time.
- Monitoring time to thrombolytic initiation and bleeding complication rates.
Main Results:
- The 30-minute goal for thrombolytic initiation was challenging to sustain, highlighting the need for ongoing collaboration.
- Bleeding complication rates remained within expected ranges.
- Concurrent data collection facilitated immediate problem-solving and care enhancement.
Conclusions:
- A multidisciplinary team utilizing continuous improvement and real-time data analysis can improve care delivery for high-risk procedures.
- Vigilant, coordinated care is essential for minimizing complications in catheter-directed thrombolysis.
- Real-time problem-solving is effective for optimizing patient outcomes in specialized vascular interventions.
Abstract:
Catheter directed infusion of thrombolytics, though beneficial in restoring blood flow to an ischemic limb, remains a high-risk procedure requiring vigilant, coordinated care to prevent complications. A multidisciplinary team that included staff from all care settings and disciplines was formed. This team used a continuous improvement process to identify system problems, analyze work processes and develop tools to standardize and guide care. Because catheter-directed peripheral thrombolytic infusion is a low volume, high-risk procedure, data were collected concurrently over 4 years on all patients. Concurrent data collection identified problems as they occurred, allowing problem analysis and resolution to begin immediately. The outcomes measured included time to initiation of thrombolytic (goal was 30 minutes or less) and the incidence of bleeding complications. Data from 61 cases from November 2003 through November 2007 were analyzed. Although the 30-minute goal for the initiation of the thrombolytic infusion was met for some time periods, it was difficult to sustain and required continued communication and collaboration. The incidence of bleeding complications were within an expected range. Concurrent data collection with real-time problem solving in a team setting enhanced the delivery of safe, effective care to a high-risk, low-volume population.
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