Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Influenza A(H1N1): a widening spectrum?

P W Gill1, A M Murphy, A L Cunningham

  • 1Department of Virology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, NSW.

The Medical Journal of Australia
|September 16, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Re-interpreting the Appropriate Growth Hormone Response to Hypoglycaemia.

Irish medical journal·2023
Same author

Intestinal microbiota and their metabolic contribution to type 2 diabetes and obesity.

Journal of diabetes and metabolic disorders·2021
Same author

Gut microbiota influence in type 2 diabetes mellitus (T2DM).

Gut pathogens·2021
Same author

A review on gut microbiota: a central factor in the pathophysiology of obesity.

Lipids in health and disease·2021
Same author

Evaluating documentation of social history in paediatric medical notes at a regional paediatric centre - a quality improvement initiative.

BMC pediatrics·2020
Same author

Bereavement Counselling for Healthcare Workers in the Aftermath of Child Death

Irish medical journal·2019

The H1N1 influenza virus, which reappeared in 1977, initially affected younger populations. Continued antigenic drift led to the virus attacking a wider age range by 1988.

Area of Science:

  • Virology
  • Epidemiology
  • Immunology

Background:

  • The H1N1 influenza subtype resurged globally in 1977 after being displaced by other strains.
  • The reappeared H1N1 strain, A/USSR/90/77, primarily infected individuals born after the 1950s, causing minimal mortality.
  • This strain did not displace the co-circulating H3N2 influenza virus.

Purpose of the Study:

  • To investigate the incidence of H1N1 influenza from 1977 to 1988 in unvaccinated individuals.
  • To assess the impact of ongoing antigenic drift on the H1N1 virus's characteristics and spread.
  • To determine if viral evolution would broaden the age groups affected by H1N1.

Main Methods:

  • A prospective study involving general practitioners and virological confirmation.

Related Experiment Videos

  • Inclusion of unvaccinated volunteers, with high-risk participants encouraged to be vaccinated and withdraw.
  • Monitoring of participants over the study period, with varying numbers at different stages (287 in 1977-1981, 207 by 1988).

    • Main Results:

    • The initial H1N1 strains (A/USSR/90/77, A/Brazil/11/78) predominantly infected younger individuals with limited prior H1N1 exposure.
    • By the 1988 epidemic, the H1N1 strain A/Taiwan/1/86 demonstrated an expanded age range of attack compared to earlier strains.
    • Negligible mortality was observed during the early H1N1 pandemics, largely due to the low risk of severe outcomes in the younger demographic.

    Conclusions:

    • Continued antigenic drift in H1N1 influenza viruses is likely to result in a progressively wider spectrum of age groups being affected.
    • The findings suggest a dynamic evolution of H1N1, necessitating ongoing surveillance and potential vaccine updates.