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Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...

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Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
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Using differential gene expression to study Entamoeba histolytica pathogenesis.

Carol A Gilchrist1, William A Petri

  • 1Division of Infectious Diseases and International Health, Departments of Medicine, Microbiology and Pathology, University of Virginia, PO Box 801340, Charlottesville, VA 22908-1340, USA.

Trends in Parasitology
|February 17, 2009
PubMed
Summary
This summary is machine-generated.

The Entamoeba histolytica genome enables gene expression studies to understand its life cycle and virulence. This review explores how differential gene expression impacts this human protozoan parasite.

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Area of Science:

  • Genomics
  • Parasitology
  • Molecular Biology

Background:

  • Entamoeba histolytica is a protozoan parasite causing amoebiasis in humans.
  • Understanding its gene expression is crucial for developing control strategies.

Purpose of the Study:

  • To review the association between differential gene expression and the life cycle of Entamoeba histolytica.
  • To explore the contribution of gene expression to the virulence of this parasite.

Main Methods:

  • Genome-wide expression profiling techniques.
  • Bioinformatic analysis of gene expression data.
  • Correlation of gene expression patterns with parasite biology.

Main Results:

  • The Entamoeba histolytica genome release has enabled advanced gene expression surveys.
  • Differential gene expression is linked to key stages in the parasite's life cycle.
  • Specific gene expression profiles correlate with the parasite's virulence factors.

Conclusions:

  • Gene expression analysis provides critical insights into Entamoeba histolytica biology.
  • Targeting differential gene expression could offer new avenues for therapeutic intervention.
  • Further research into gene expression will enhance our understanding of amoebiasis pathogenesis.