Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sublingual apomorphine solution in Parkinson's disease.

P K Panegyres1, S J Graham, B K Williams

  • 1Department of Neurology, Westmead Hospital, NSW.

The Medical Journal of Australia
|September 16, 1991
PubMed
Summary

Sublingual apomorphine offers rapid relief for Parkinson's disease "off" periods, with faster onset but shorter duration than levodopa. This study compared oral levodopa, subcutaneous, and sublingual apomorphine in Parkinson's patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hematoma at the insertion of the medial rectus mimicking a conjunctival melanoma.

Journal francais d'ophtalmologie·2023
Same author

Cutaneous features of Zika virus infection: a clinicopathological overview.

Clinical and experimental dermatology·2018
Same author

Repeated Dietary Exposure to Low Levels of Domoic Acid and Problems with Everyday Memory: Research to Public Health Outreach.

Toxins·2018
Same author

Environmental and health effects of the herbicide glyphosate.

The Science of the total environment·2017
Same author

Neonatal sepsis in rural India: timing, microbiology and antibiotic resistance in a population-based prospective study in the community setting.

Journal of perinatology : official journal of the California Perinatal Association·2017
Same author

Longitudinal development of match-running performance in elite male youth soccer players.

Scandinavian journal of medicine & science in sports·2015

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Idiopathic Parkinson's disease (PD) is characterized by motor fluctuations, including "end of dose deterioration."
  • Levodopa is a primary treatment, but its effectiveness can wane between doses.

Purpose of the Study:

  • To compare the efficacy, onset, and duration of single doses of oral levodopa, subcutaneous apomorphine, and sublingual apomorphine.
  • To evaluate these treatments in patients experiencing "end of dose deterioration" in Parkinson's disease.

Main Methods:

  • A single-blind, placebo-controlled comparative study.
  • Five patients with idiopathic Parkinson's disease received domperidone to mitigate nausea.
  • Treatments administered included oral levodopa, subcutaneous apomorphine (1-3 mg), and sublingual apomorphine (10-30 mg).

Related Experiment Videos

Main Results:

  • Maximal efficacy across all three treatments was comparable.
  • Both subcutaneous and sublingual apomorphine demonstrated a significantly faster onset of effect compared to oral levodopa.
  • However, the duration of effect for both apomorphine formulations was also significantly shorter than that of levodopa.

Conclusions:

  • Sublingual apomorphine presents a practical option for quickly alleviating "off" periods in Parkinson's disease patients undergoing long-term levodopa therapy.
  • Apomorphine's rapid onset may be beneficial for acute symptom management, despite its shorter duration.