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Related Experiment Video

Updated: Jun 25, 2026

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts
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Published on: February 17, 2023

Low energy defibrillation in human cardiac tissue: a simulation study.

Stuart W Morgan1, Gernot Plank, Irina V Biktasheva

  • 1Department of Mathematical Sciences, University of Liverpool, Liverpool, United Kingdom.

Biophysical Journal
|February 17, 2009
PubMed
Summary

Feedback-controlled resonant drift pacing shows promise for low energy defibrillation. This method can terminate cardiac reentry using significantly weaker shocks than conventional defibrillation, potentially improving implantable cardioverter defibrillator therapy.

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Area of Science:

  • Biomedical Engineering
  • Computational Biology
  • Cardiac Electrophysiology

Background:

  • Antitachycardia pacing is a suboptimal low energy defibrillation method.
  • High-voltage defibrillation shocks cause adverse side effects.
  • Low energy defibrillation could expand implantable cardioverter defibrillator (ICD) therapy options.

Purpose of the Study:

  • To assess the effectiveness of feedback-controlled resonant drift pacing for low energy defibrillation.
  • To investigate resonant drift pacing's potential to terminate cardiac reentry.
  • To compare the required shock strength with conventional defibrillation.

Main Methods:

  • Computer simulations using a bidomain model of cardiac tissue.
  • Incorporation of human atrial ionic kinetics.

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Last Updated: Jun 25, 2026

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts
07:56

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Published on: February 17, 2023

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  • Initiation of reentry and application of feedback-controlled resonant drift pacing.

    • Main Results:

    • Resonant drift pacing successfully terminated reentry in simulations.
    • Shock strength required was one order of magnitude weaker than conventional defibrillation.
    • Stimulation successfully moved the core of reentrant patterns.

    Conclusions:

    • Feedback-controlled resonant drift pacing can terminate reentry at a fraction of current defibrillation shock strengths.
    • This method may succeed where antitachycardia pacing fails due to its feedback mechanisms.
    • Numerical simulations revealed critical details for successful implementation.