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Neuroimaging as a basis for rational stem cell therapy.

Stephen Ashwal¹, Andre Obenaus, Evan Y Snyder

¹Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California 92354, USA. sashwal@llu.edu

Pediatric Neurology

|February 17, 2009

Summary

Advanced magnetic resonance imaging and spectroscopy offer noninvasive methods to assess neonatal hypoxic-ischemic brain injury severity and treatment response. These techniques are crucial for validating neuroprotective therapies in clinical trials.

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Area of Science:

Neuroscience
Medical Imaging
Neonatal Research

Background:

Neonatal hypoxic-ischemic brain injury is a significant cause of long-term disability.
Accurate assessment of injury severity and treatment response is critical for clinical trials.

Purpose of the Study:

To review advanced imaging and spectroscopy techniques for evaluating neonatal brain injury.
To discuss the application of these methods in assessing neuroprotection and stem cell therapies.

Main Methods:

Utilizes advanced magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (MRS).
Focuses on noninvasive, serial data acquisition for brain structure and metabolic activity.
Emphasizes validation in animal models for translational research.

Main Results:

Imaging and MRS can assess ischemic injury severity and monitor its progression.
Preliminary data show imaging can track neural stem cell migration, proliferation, and location post-implantation.
These methods provide insights into recovery and response to treatment.

Conclusions:

Advanced MRI and MRS are valuable tools for evaluating neonatal brain injury and treatment efficacy.
Imaging facilitates monitoring of neuroprotective treatments, including neural stem cell therapies.
These techniques are expected to enhance the safety and effectiveness of future clinical trials.