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Updated: Jun 25, 2026

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
Published on: May 9, 2025
[Expression of heparin-binding epidermal growth factor-like growth factor in patients with gastric carcinoma]
Guo-rong Wang1, Yan Zheng, Xiang-ming Che
1Department of General Surgery, People's Hospital of Shaanxi Province, Xi'an 710068, China. wangguorong66@126.com
Objective:
To investigate the expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in patients with gastric carcinoma in different stages.
Methods:
The expressions of HB-EGF protein and mRNA in normal gastric tissues, metaplasic intestinal mucosa, early-stage gastric cancer and advanced-stage gastric cancer tissues were detected by immunohistochemistry and in situ hybridization.
Results:
HB-EGF expression was only detected in the parietal cells of the gastric fundic glands and in gastrin cells of the pyloric glands in normal gastric tissues. Weak HB-EGF expression was detected in the epithelial cells of the gastric mucosa in intestinal metaplasic mucosa, and the expression increased in all layers of the gastric mucosa in early-stage gastric cancer. Intense HB-EGF expression was observed in advanced gastric cancer.
Conclusion:
Increased HB-EGF expression may be implicated in the pathogenesis and development of gastric carcinoma.
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