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Updated: Jun 25, 2026

Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria
Published on: September 20, 2024
Differential expression of sigH paralogs during growth and under different stress conditions in Mycobacterium
Anirudh K Singh1, Bhupendra N Singh
1Division of Microbiology, Central Drug Research Institute, Lucknow 226 001, India. bhupendransingh@gmail.com
Abstract:
SigH regulates a transcriptional network that responds to heat and oxidative stress in mycobacteria. Seven sigH paralogs are reported to exist in the Mycobacterium smegmatis genome. A comprehensive real-time reverse transcriptase PCR analysis during different stages of growth and upon exposure to various stress conditions and antimycobacterial compounds showed differential expression of sigH paralogs during stationary phase and severalfold increases in the levels of transcription of sigH1, sigH4, sigH5, sigH6, and sigH7 under specific stress conditions.
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