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Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits.

Xiang-ming Zha1, Runping Wang, Dan M Collier

  • 1Howard Hughes Medical Institute and Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

Proceedings of the National Academy of Sciences of the United States of America
|February 17, 2009
PubMed
Summary

Oxidants like H(2)O(2) alter acid-sensing ion channel-1a (ASIC1a) structure by forming inter-subunit disulfide bonds. This structural change reduces ASIC1a cell surface expression and proton-gated current, revealing a redox-based regulatory mechanism.

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