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Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
Published on: February 3, 2014
Right ventricular function in patients with severe interstitial lung disease: a Tissue Doppler imaging study.
J Nowak1, D Jastrzebski, W Streb
1Third Department of Cardiology, Silesian Center for Heart Diseases, Medical University of Silesia, Zabrze, Poland.
Summary
Severe interstitial lung disease (ILD) impacts right ventricular (RV) systolic function. Tissue Doppler imaging (TDI) and echocardiography reveal RV dysfunction in advanced ILD patients awaiting lung transplantation.
Area of Science:
- Cardiology
- Pulmonology
- Medical Imaging
Background:
- Pulmonary diseases can lead to right ventricular (RV) dysfunction.
- Tissue Doppler imaging (TDI) is a valuable tool for assessing RV regional dysfunction.
Purpose of the Study:
- To evaluate RV dysfunction in patients with severe interstitial lung diseases (ILD) using TDI and conventional transthoracic echocardiography (TTE).
- To compare RV function between ILD patients eligible for lung transplantation (LT) and those awaiting LT.
Main Methods:
- Studied 40 end-stage ILD patients referred for LT, divided into an active group (18 patients meeting LT criteria) and a waiting group (22 patients).
- Utilized TDI to measure longitudinal peak systolic strain rate (SR) and time to peak velocity (TpVEL).
- Employed conventional TTE to assess tricuspid annulus plane systolic excursion (TAPSE) and pulmonary artery acceleration time (PVAT).
Main Results:
- The active group showed significantly more negative RV outflow tract SR and shorter septal TpVEL compared to the waiting group.
- Active group patients had significantly lower TAPSE and PVAT values than the waiting group.
- No significant differences were observed in other RV function parameters between the groups.
Conclusions:
- The severity of lung disease in ILD patients significantly affects RV systolic function.
- Both TDI and conventional echocardiographic parameters reflect RV systolic dysfunction in severe ILD.