Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Liver cirrhosis in a patient with alcohol dependence and autoimmune hepatitis.

European review for medical and pharmacological sciences·2024
Same author

Final analysis of phase II results with cemiplimab in metastatic basal cell carcinoma after hedgehog pathway inhibitors.

Annals of oncology : official journal of the European Society for Medical Oncology·2023
Same author

Visual impairment and self-limited placoid neuroretinitis as a possible early sign of COVID-19: A case report and multimodal analysis.

Journal francais d'ophtalmologie·2023
Same author

Serum biomarkers predictive of cirrhosis in alcoholic liver disease as an alternative to ARFI-SW elastography.

European review for medical and pharmacological sciences·2023
Same author

Evaluating the potential cost savings from inpatient dermatology consultations.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Treatment of granuloma annulare and related granulomatous diseases with sulphasalazine: a series of 16 cases.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same journal

Correction to: Autoinflammatory diseases: why they should matter to the dermatologist.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2021
Same journal

Correction to: Actinic keratoses: when and how to treat a single lesion.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2021
Same journal

Correction to: Thick melanoma in Tuscany.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2021
Same journal

Spastic quadriplegia following intradermal use of hydrogen peroxide in the tardive curettage procedure for the treatment of a giant congenital nevus.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2021
Same journal

Genetic mutations in primary malignant melanoma of the esophagus: case report and literature review.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2020
Same journal

Cutaneous manifestations in an Italian military COVID hub.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2020
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Metastatic malignant melanoma.

S N Markovic1, L A Erickson, T J Flotte

  • 1Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA. markovic.svetomir@mayo.edu

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia
|February 17, 2009
PubMed
Summary
This summary is machine-generated.

Metastatic malignant melanoma has a poor prognosis, with limited survival rates. Recent advancements in diagnostics and therapeutics offer new hope for improving outcomes in patients with this incurable cancer.

More Related Videos

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
07:31

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs

Published on: May 24, 2016

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Related Experiment Videos

Last Updated: Jun 25, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
07:31

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs

Published on: May 24, 2016

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Area of Science:

  • Oncology
  • Dermatology
  • Cancer Research

Background:

  • Metastatic malignant melanoma is an aggressive cancer with a dismal prognosis and limited treatment options.
  • Current systemic therapies have not significantly improved overall survival rates for patients with advanced melanoma.
  • Early-stage melanoma detected on the skin is curable with surgical resection.

Purpose of the Study:

  • To review the current state-of-the-art in diagnostics and therapeutics for metastatic melanoma.
  • To highlight recent advancements that are improving understanding and treatment strategies.
  • To emphasize the importance of multi-disciplinary clinical management for metastatic melanoma patients.

Main Methods:

  • Comprehensive literature review of recent diagnostic and therapeutic developments in metastatic melanoma.
  • Analysis of current systemic therapy efficacy and impact on overall survival.
  • Emphasis on the integration of multi-disciplinary approaches in clinical management.

Main Results:

  • Despite poor prognosis, recent innovations in diagnostics and therapeutics are emerging.
  • New therapeutic targets and strategies show promise for changing clinical outcomes.
  • Multi-disciplinary management is crucial for optimizing patient care.

Conclusions:

  • While metastatic melanoma remains incurable, recent advancements offer significant hope.
  • Innovative diagnostic and therapeutic strategies are poised to improve patient survival.
  • Integrated, multi-disciplinary clinical management is essential for advancing metastatic melanoma care.