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Related Concept Videos

Glomerular Filtration01:15

Glomerular Filtration

The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Types of Membrane Protrusions01:28

Types of Membrane Protrusions

The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections with a...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...

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Related Experiment Video

Updated: Jun 25, 2026

Generation of Patient-Derived Podocytes from Skin Biopsies
08:52

Generation of Patient-Derived Podocytes from Skin Biopsies

Published on: May 26, 2023

Flying podocytes.

Matias Simons1, Tobias B Huber

  • 1Renal Division, University Hospital Freiburg, Freiburg, Germany.

Kidney International
|February 17, 2009
PubMed
Summary
This summary is machine-generated.

Researchers identified a Drosophila nephrocyte as a podocyte model, offering new insights into kidney cell biology and disease progression. This discovery advances understanding of glomerular diseases and podocyte function.

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Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions
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Imaging of Podocytic Proteins Nephrin, Actin, and Podocin with Expansion Microscopy
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Imaging of Podocytic Proteins Nephrin, Actin, and Podocin with Expansion Microscopy

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Last Updated: Jun 25, 2026

Generation of Patient-Derived Podocytes from Skin Biopsies
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Published on: May 26, 2023

Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions
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Imaging of Podocytic Proteins Nephrin, Actin, and Podocin with Expansion Microscopy
06:18

Imaging of Podocytic Proteins Nephrin, Actin, and Podocin with Expansion Microscopy

Published on: April 23, 2021

Area of Science:

  • Nephrology
  • Developmental Biology
  • Genetics

Background:

  • Podocytes are crucial in rare genetic and common human glomerular diseases.
  • Understanding podocyte function is key to treating kidney diseases.

Purpose of the Study:

  • To investigate the podocyte-like cell type in Drosophila, termed nephrocytes.
  • To explore the potential of Drosophila nephrocytes as a model for mammalian podocyte research.

Main Methods:

  • Comparative analysis of Drosophila nephrocytes and mammalian podocytes.
  • Investigation of the slit diaphragm structure in nephrocytes.

Main Results:

  • Drosophila nephrocytes exhibit striking similarities to mammalian podocytes.
  • Nephrocytes possess a nephrin-based slit diaphragm, analogous to mammalian counterparts.

Conclusions:

  • Drosophila nephrocytes represent a valuable model system for studying podocyte biology.
  • This discovery may open new research avenues for understanding podocyte pathophysiology and glomerular diseases.