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Updated: Jun 25, 2026

An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis
Published on: September 15, 2015
Systems biology: Functional analysis of natural microbial consortia using community proteomics
Nathan C VerBerkmoes1, Vincent J Denef, Robert L Hettich
1Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA. verberkmoesn@ornl.gov
Abstract:
We know very little about the metabolic functioning and evolutionary dynamics of microbial communities. Recent advances in comprehensive, sequencing-based methods, however, are laying a molecular foundation for new insights into how microbial communities shape the Earth's biosphere. Here we explore the convergence of microbial ecology, genomics, biological mass spectrometry and informatics that form the new field of microbial community proteogenomics. We discuss the first applications of proteogenomics and its potential for studying the physiology, ecology and evolution of microbial populations and communities.
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