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Related Experiment Videos

Incidentally discovered adrenal masses.

R H Caplan1, W A Kisken, C M Huiras

  • 1Department of Internal Medicine, Gundersen Clinic, Ltd., La Crosse, Wisconsin.

Minnesota Medicine
|August 1, 1991
PubMed
Summary
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Incidental adrenal masses can secrete hormones, like cortisol, even when subclinical. Early lab evaluation and considering removal for masses over 3 cm are recommended.

Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Radiology

Background:

  • Incidentally discovered adrenal masses are common findings on imaging.
  • The hormonal activity and malignant potential of these masses are often unknown.

Purpose of the Study:

  • To retrospectively analyze outcomes and management of incidentally discovered adrenal masses.
  • To evaluate the clinical significance of subclinical hormone secretion and recommend diagnostic and management strategies.

Main Methods:

  • Retrospective review of 23 patients with incidentally discovered adrenal masses.
  • Analysis of surgical outcomes, pathological findings, and laboratory evaluations for hormone secretion.

Main Results:

  • Two patients with subclinical cortisol secretion developed adrenal insufficiency post-surgery.

Related Experiment Videos

  • One patient experienced a hypertensive crisis due to an undiagnosed pheochromocytoma.
  • Malignant masses (angiosarcoma, adenocarcinoma, neuroblastoma) were identified in three patients.

    • Conclusions:

    • Subclinical hormone secretion, particularly cortisol, is a significant risk associated with incidental adrenal masses.
    • Recommend overnight dexamethasone suppression test for evaluation.
    • Surgical removal is advised for masses >3 cm; non-surgical candidates require serial imaging and clinical reassessment.