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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
IL-22: a critical mediator in mucosal host defense
1Division of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. shean.aujla@chp.edu
Journal of Molecular Medicine (Berlin, Germany)
|February 17, 2009
Summary
Interleukin-22 (IL-22) is a cytokine produced by Th17 cells that plays a key role in mucosal immunity, particularly in the digestive, skin, and respiratory systems. It aids in host defense against pathogens but also contributes to autoimmune diseases.
Area of Science:
- Immunology
- Cell Biology
Background:
- Interleukin-22 (IL-22) is a member of the IL-10 cytokine family.
- It is primarily produced by Th17 cells and targets epithelial cells in the digestive, skin, and respiratory systems.
- IL-22 mediates epithelial innate immunity against various pathogens.
Purpose of the Study:
- To review the known functions of IL-22.
- To highlight IL-22's role in mucosal host defense.
Main Methods:
- Literature review of current studies on IL-22.
- Analysis of IL-22's targeting cells and receptor expression.
- Examination of IL-22's role in host defense and autoimmune diseases.
Main Results:
- IL-22 is crucial for mucosal immunity and host defense, especially against Gram-negative bacteria in the gut and lung.
- The IL-22 receptor (IL-22R) is exclusively expressed in target tissues, enabling localized immune responses.
- IL-22 exhibits complex pro-inflammatory, anti-inflammatory, and autoimmune effects, implicated in conditions like psoriasis.
Conclusions:
- IL-22 is a critical cytokine for epithelial innate immunity and mucosal defense.
- Its multifaceted roles in host defense and autoimmune processes warrant further investigation.
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