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The bovine dilated cardiomyopathy locus maps to a 1.0-Mb interval on chromosome 18

Marta Owczarek-Lipska1, Catherine Denis, André Eggen

  • 1Institute of Genetics, Vetsuisse Faculty, University of Berne, Bremgartenstrasse 109a, 3001, Berne, Switzerland. marta.owczarek@itz.unibe.ch

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|February 17, 2009
PubMed

Insights

Bovine dilated cardiomyopathy (BDCMP) is an inherited heart muscle disorder in cattle. This study fine-mapped the BDCMP genetic locus to a 1.0 Mb region on bovine chromosome 18, aiding future genetic research.

Area of Science:

  • Veterinary Genetics
  • Cardiovascular Pathology
  • Animal Breeding

Background:

  • Cardiomyopathies are myocardial diseases causing cardiac dysfunction, heart failure, and potentially sudden death, often requiring heart transplantation in humans.
  • Bovine dilated cardiomyopathy (BDCMP) is an inherited heart muscle disorder affecting Holstein-Friesian cattle, characterized by cardiac enlargement, ventricular remodeling, and chamber dilatation.
  • Previous research traced BDCMP to a specific Holstein-Friesian bull and proposed an autosomal recessive inheritance pattern, with the disease locus mapped to bovine chromosome 18 (BTA18).

Purpose of the Study:

  • To fine-map the genetic locus associated with Bovine Dilated Cardiomyopathy (BDCMP).
  • To refine the location of the BDCMP disease locus on bovine chromosome 18 (BTA18) using advanced genetic mapping techniques.

Main Methods:

  • Employed a combined strategy of homozygosity mapping and association study for fine mapping the BDCMP locus.
  • Constructed a Bacterial Artificial Chromosome (BAC) contig of 2.9 Mb to establish marker order on BTA18.
  • Utilized microsatellite markers, including DIK3006 and MSBDCMP51, to delineate the critical interval.

Main Results:

  • Successfully fine-mapped the BDCMP locus to a refined interval of 1.0 Mb on BTA18.
  • Identified the critical disease locus as a gene-rich region.
  • Established the flanking microsatellite markers for the BDCMP locus as DIK3006 and MSBDCMP51.

Conclusions:

  • The BDCMP genetic locus has been precisely localized to a 1.0 Mb region on BTA18, flanked by specific microsatellite markers.
  • This refined genetic map provides a foundation for identifying the causative gene(s) responsible for BDCMP.
  • Understanding the genetic basis of BDCMP is crucial for breeding programs aimed at reducing the incidence of this cardiac disorder in cattle.

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