Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In memoriam: Richard O. Hynes.

The Journal of cell biology·2026
Same author

Identification of novel genes regulating the development of the palate.

Developmental dynamics : an official publication of the American Association of Anatomists·2025
Same author

Correction: Importance of Donor-Derived and Recipient-Derived Selectins in Cardiac Allograft Rejection.

Journal of the American Society of Nephrology : JASN·2025
Same author

Mesodermal fibronectin controls cell shape, polarity, and mechanotransduction in the second heart field during cardiac outflow tract development.

Developmental cell·2024
Same author

Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease.

Circulation research·2024
Same author

Identification of a Gene Signature That Predicts Dependence upon YAP/TAZ-TEAD.

Cancers·2024
Same journal

Endothelial Notch1 drives multicellular remodelling during hyaloid vessel regression.

Angiogenesis·2026
Same journal

Endothelial protein C receptor and the endothelial progenitor paradigm: towards a functional definition at last.

Angiogenesis·2026
Same journal

Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer.

Angiogenesis·2026
Same journal

A possible microvascular vulnerability in carotid artery dissection: insights from nailfold capillaroscopy.

Angiogenesis·2026
Same journal

miR-150 controls developmental angiogenesis via ribosome biogenesis-dependent regulation of Notch signaling.

Angiogenesis·2026
Same journal

MCC links Wnt/PCP signaling to endothelial polarity and vascular remodeling.

Angiogenesis·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
07:52

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

Fibronectins in vascular morphogenesis.

Sophie Astrof1, Richard O Hynes

  • 1Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA. soa2004@med.cornell.edu

Angiogenesis
|February 17, 2009
PubMed
Summary
This summary is machine-generated.

Fibronectin, a key extracellular matrix protein, is vital for cardiovascular development. Its upregulation in disease suggests roles in vascular conditions and tumor growth, though molecular functions require further study.

More Related Videos

Measuring the Confluence of iPSCs Using an Automated Imaging System
11:39

Measuring the Confluence of iPSCs Using an Automated Imaging System

Published on: June 10, 2020

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay
07:21

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay

Published on: December 26, 2019

Related Experiment Videos

Last Updated: Jun 25, 2026

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
07:52

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

Measuring the Confluence of iPSCs Using an Automated Imaging System
11:39

Measuring the Confluence of iPSCs Using an Automated Imaging System

Published on: June 10, 2020

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay
07:21

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay

Published on: December 26, 2019

Area of Science:

  • Cardiovascular biology
  • Extracellular matrix research
  • Developmental biology

Background:

  • Fibronectin is an extracellular matrix protein essential for cardiovascular development in vertebrates.
  • Fibronectin splice variants with EIIIA and EIIIB domains are upregulated during embryogenesis and in pathological conditions like atherosclerosis, cardiac hypertrophy, and tumorigenesis.
  • The precise molecular roles of fibronectin and its variants in these processes remain unclear.

Purpose of the Study:

  • To review genetic studies on fibronectin function during embryonic cardiovascular development.
  • To discuss the potential roles of fibronectin in vascular disease.
  • To explore fibronectin's involvement in tumor angiogenesis.

Main Methods:

  • Review of genetic studies.
  • Analysis of fibronectin expression patterns.
  • Discussion of existing literature on fibronectin's roles.

Main Results:

  • Fibronectin is crucial for cardiovascular development.
  • Upregulation of fibronectin variants occurs in embryogenesis and various pathologies.
  • Potential roles in vascular disease and tumor angiogenesis are suggested.

Conclusions:

  • Fibronectin is indispensable for cardiovascular development.
  • Fibronectin's involvement in pathological angiogenesis warrants further investigation.
  • Understanding fibronectin's molecular mechanisms could offer therapeutic targets.