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Updated: Jun 25, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
An efficient synthesis of substituted 2-iminothiazolidin-4-one and thiadiazoloquinazolinone derivatives
Ali Ahmadi1, Kazem Saidi, Hojattollah Khabazzadeh
1Department of Chemistry, Shahid Bahonar University of Kerman, 76169 Kerman, Iran.
Abstract:
A convenient synthesis of functionalized 2-iminothiazolidin-4-ones and thiadiazoloquinazolinones has been achieved by the reaction of dialkyl acetylenedicarboxylates (DAAD) with 1-pheny-3-pyridin-2-yl-thiourea (1) and 3-amino-2-mercapto-3H-quinazolin-4-one (8), respectively. The starting materials for these processes were prepared from phenyl isothiocyanate, 2-aminopyridine for (1) and anthranilic acid, carbon disulfide, hydrazine for (8). Treatment of these compounds with DAAD resulted in the formation of an intermediate that readily underwent intramolecular cyclization to afford functionalized five membered heterocyclic rings was formed.
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