Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Addition of malignancy into the CHADS2/CHA2DS2VASc score: better prediction of stroke risk in individuals with cancer and atrial fibrillation.

Cardio-oncology (London, England)·2026
Same author

Guidelines Can Be Lifesaving: The Vermont Model of Thromboprophylaxis Implementation.

JCO oncology practice·2026
Same author

Antithrombotic therapy at the end-of-life-continue or stop?

Research and practice in thrombosis and haemostasis·2026
Same author

Phase 2 trial of exercise and low-dose ibuprofen for cancer-related cognitive impairment in patients receiving chemotherapy.

Cancer·2026
Same author

Platelets regulate glioblastoma growth and immunity via sex-dependent PAR4 - Estrogen receptor beta signaling.

bioRxiv : the preprint server for biology·2026
Same author

Outcomes associated with left atrial appendage occlusion in patients with cancer-associated atrial fibrillation: a real-world propensity-matched analysis.

Cardio-oncology (London, England)·2026

Related Experiment Video

Updated: Jun 25, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Tissue factor and VEGF expression in prostate carcinoma: a tissue microarray study.

Jorge L Yao1, Charlotte K Ryan, Charles W Francis

  • 1Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA. jorge yao@urmc.rochester.edu

Cancer Investigation
|February 17, 2009
PubMed
Summary
This summary is machine-generated.

Tissue factor (TF) drives coagulation and tumor growth. Higher TF and vascular endothelial growth factor (VEGF) expression in prostate cancer (PCa) suggests a link to angiogenesis and tumor aggressiveness.

More Related Videos

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging
08:40

Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging

Published on: April 8, 2016

Related Experiment Videos

Last Updated: Jun 25, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging
08:40

Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging

Published on: April 8, 2016

Area of Science:

  • Oncology
  • Vascular Biology
  • Biochemistry

Background:

  • Tissue factor (TF) initiates coagulation and is implicated in tumor growth and metastasis.
  • TF may contribute to angiogenesis, a key process in tumor progression.

Purpose of the Study:

  • To evaluate TF expression in benign and malignant prostate tissues.
  • To correlate TF expression with vascular endothelial growth factor (VEGF) in prostate cancer (PCa).

Main Methods:

  • Utilized a tissue microarray (TMA) from 80 prostatectomy specimens.
  • Performed immunohistochemical staining for TF and VEGF.
  • Scored staining intensity in epithelial cells using the German Immunoreactive Score.

Main Results:

  • TF expression was significantly higher in PCa compared to benign prostate (BP) and prostatic intraepithelial neoplasia (PIN) tissues.
  • VEGF expression was significantly lower in BP compared to PCa tissues.
  • Most PCa samples positive for TF also showed positive VEGF staining, indicating a correlation.

Conclusions:

  • Findings support a link between TF expression and angiogenesis in PCa.
  • Further research into TF-mediated pathways in PCa aggressiveness is warranted.
  • Anti-TF agents may hold potential for PCa treatment.