Related Experiment Video
Updated: Jun 25, 2026
Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
Published on: January 25, 2015
A first report of radioembolization for hepatic metastases from ocular melanoma
Andrew S Kennedy1, Charles Nutting, Tobias Jakobs
1Wake Radiology Oncology, Cary, North Carolina 27518, USA. akennedy@wakerad.com
Background:
Ocular melanoma (OM) metastasizes to the liver and is rapidly fatal despite aggressive therapy. Yttrium-90 microspheres (radioembolization) delivered via the hepatic artery is an established and effective approach for primary and metastatic hepatic tumors, although (90)Y use in OM has not been reported previously.
Methods:
A retrospective review was performed for all patients with OM who received radioembolization at 5 centers.
Results:
11 patients received 12 treatments with a median activity of 1.55 GBq delivered per treatment. Toxicity was minimal, with PET/CT at 3 months posttreatment showing a response in all patients; 1 patient had a complete response.
Conclusions:
Radioembolization can control hepatic metastases of OM with very few side effects.
