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Updated: Jun 25, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Short synthesis and antiviral activity of acyclic phosphonic acid nucleoside analogues
Lian Jin Liu1, Jin Cheol Yoo, Joon Hee Hong
1College of Pharmacy, Chosun University, Kwangju, Republic of Korea.
Abstract:
An efficient route for synthesizing novel allylic and cyclopropanoid phosphonic acid nucleoside analogues is described. The condensation of the bromine derivatives 6 and 18 with nucleoside bases (A, U, T, C, G) under standard nucleophilic substitution and deprotection conditions, afforded the target phosphonic acid nucleoside analogues. These compounds were evaluated for their antiviral properties against various viruses. Cyclopropanoid phosphonic adenine nucleoside analogue 23 showed significant anti-HIV activity.
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