Related Experiment Video
Updated: Jun 25, 2026

Chemical Cartography Approaches to Study Trypanosomatid Infection
Published on: January 21, 2022
Finite mixture models for mapping spatially dependent disease counts
Marco Alfó1, Luciano Nieddu, Donatella Vicari
1Dipartimento di Statistica, Sapienza - Università di Roma, Italy. marco.alfo@uniroma1.it
Abstract:
A vast literature has recently been concerned with the analysis of variation in disease counts recorded across geographical areas with the aim of detecting clusters of regions with homogeneous behavior. Most of the proposed modeling approaches have been discussed for the univariate case and only very recently spatial models have been extended to predict more than one outcome simultaneously. In this paper we extend the standard finite mixture models to the analysis of multiple, spatially correlated, counts. Dependence among outcomes is modeled using a set of correlated random effects and estimation is carried out by numerical integration through an EM algorithm without assuming any specific parametric distribution for the random effects. The spatial structure is captured by the use of a Gibbs representation for the prior probabilities of component membership through a Strauss-like model. The proposed model is illustrated using real data.
Related Concept Videos
Mechanistic Models: Compartment Models in Individual and Population Analysis
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Multicompartment Models: Overview
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Pharmacodynamic Models: Additive and Proportional Drug Effect Model
Linear Approximations
