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Updated: Jun 25, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Reversible MRI abnormalities in a patient with recurrent status migrainosus
S Gentile1, I Rainero, D Daniele
1Neurology II-Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15-10126 Torino, Italy. sgentile@molinette.piemonte.it
Cephalalgia : an International Journal of Headache
|February 18, 2009
Summary
Status migrainosus, a severe migraine complication, may involve reversible brain swelling. This finding suggests vasogenic cerebral edema as a potential underlying mechanism in prolonged migraine attacks.
Area of Science:
- Neurology
- Neuroimaging
- Pathophysiology
Background:
- Status migrainosus is a debilitating migraine complication lasting over 72 hours.
- The underlying pathophysiological mechanisms of status migrainosus are not fully understood.
- Migraine attacks can occur with or without aura.
Observation:
- A case study of a migraine without aura patient experiencing recurrent status migrainosus.
- The patient exhibited reversible brain magnetic resonance imaging (MRI) abnormalities.
- Positron emission tomography (PET) confirmed these imaging findings.
Findings:
- Status migrainosus episodes were associated with recurrent and reversible brain MRI abnormalities.
- These abnormalities suggest a potential link between prolonged migraine and cerebral edema.
- Vasogenic cerebral edema is indicated as a possible pathophysiological mechanism.
Implications:
- This case highlights a potential association between status migrainosus and vasogenic cerebral edema.
- Neuroimaging findings may aid in understanding the pathophysiology of severe migraine.
- Further research is warranted to explore cerebral edema in status migrainosus management.
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