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Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Trichomoniasis01:18

Trichomoniasis

Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.
Bacterial Phylum Chlamydiae01:29

Bacterial Phylum Chlamydiae

The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic of...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Microbiota of the Urogenital Tract01:28

Microbiota of the Urogenital Tract

The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...

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Updated: Jun 25, 2026

Forward Genetic Approaches in Chlamydia trachomatis
09:03

Forward Genetic Approaches in Chlamydia trachomatis

Published on: October 23, 2013

Genital Chlamydia trachomatis infections.

C Bébéar1, B de Barbeyrac

  • 1Laboratoire de Bactériologie EA 3671, Infections Humaines à Mycoplasmes et Chlamydiae, CNR des Infections à Chlamydiae, Université Victor Segalen Bordeaux 2, Bordeaux, France. christiane.bebear@u-bordeaux2.fr

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|February 18, 2009
PubMed
Summary
This summary is machine-generated.

Chlamydia trachomatis infections are increasing in young, sexually active individuals, leading to serious reproductive health issues. Nucleic acid amplification tests and single-dose therapy are key for diagnosis and treatment of this common sexually transmitted infection.

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Forward Genetic Approaches in Chlamydia trachomatis
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Markerless Gene Deletion by Floxed Cassette Allelic Exchange Mutagenesis in Chlamydia trachomatis
10:35

Markerless Gene Deletion by Floxed Cassette Allelic Exchange Mutagenesis in Chlamydia trachomatis

Published on: January 30, 2020

Area of Science:

  • Infectious Diseases
  • Public Health
  • Reproductive Health

Background:

  • Chlamydia trachomatis infections are prevalent among young, sexually active populations.
  • Risk factors include multiple sexual partners and inconsistent condom use, contributing to a rising incidence over the last decade.
  • Untreated infections can cause significant long-term health consequences, including infertility and ectopic pregnancy.

Purpose of the Study:

  • To review the epidemiology, clinical impact, diagnostic methods, and treatment strategies for Chlamydia trachomatis infections.
  • To highlight recent developments such as lymphogranuloma venereum proctitis and plasmid variants.
  • To emphasize the importance of screening for this often asymptomatic infection.

Main Methods:

  • Review of current literature on Chlamydia trachomatis epidemiology, clinical outcomes, and management.
  • Discussion of diagnostic advancements, focusing on nucleic acid amplification tests (NAATs).
  • Evaluation of therapeutic interventions, including single-dose regimens.

Main Results:

  • Chlamydia trachomatis infections are a major cause of pelvic inflammatory disease, ectopic pregnancy, and infertility.
  • Nucleic acid amplification tests offer sensitive and non-invasive diagnostic capabilities.
  • Single-dose therapy has proven effective for uncomplicated infections, benefiting both patients and their partners.

Conclusions:

  • Effective screening and prompt treatment are crucial for controlling Chlamydia trachomatis infections and preventing sequelae.
  • Advances in diagnostics and therapeutics have improved patient outcomes.
  • Emerging strains and clinical presentations necessitate ongoing surveillance and adaptation of control strategies.