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Microfluidic Tools for Probing Fungal-Microbial Interactions at the Cellular Level

Microfluidic Tools for Probing Fungal-Microbial Interactions at the Cellular Level

Published on: June 23, 2022

Fungi sensing environmental stress.

R Alonso-Monge¹, E Román, D M Arana

¹Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases

|February 18, 2009

Summary

Mitogen-activated protein kinase (MAPK) pathways are vital for cell survival and adaptation. This review details MAPK cascades in Candida albicans, a key fungus causing systemic infections.

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Area of Science:

Cellular biology
Microbiology
Biochemistry

Background:

Cells must adapt to environmental changes for survival.
Signal transduction pathways enable cells to sense and respond to external stimuli.
Mitogen-activated protein kinases (MAPKs) are conserved signaling pathways crucial for cellular physiology.

Purpose of the Study:

To review the Mitogen-Activated Protein Kinase (MAPK) cascades in Candida albicans.
To highlight the role of MAPK pathways in controlling fungal virulence factors.

Main Methods:

Literature review of studies on MAPK pathways in Candida albicans.
Analysis of conserved MAPK cascades from yeast to human.

Main Results:

MAPK pathways are essential for pathogenic fungi virulence.
Specific MAPK cascades in Candida albicans have been identified and described.

Conclusions:

MAPK pathways are critical for Candida albicans survival and pathogenesis.
Understanding these pathways is key to combating fungal infections.