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Updated: Jun 25, 2026

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
Published on: February 19, 2019
Global regulators and environmental adaptation in Gram-negative pathogens
1Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, UK. cjdorman@tcd.ie
Abstract:
A powerful combination of single-gene studies and whole genome approaches has provided a wealth of information about the regulatory circuits used by bacteria to adapt to the environmental changes that are encountered during infection. The facultative intracellular pathogen Salmonella enterica will be used to illustrate how global regulators such as the nucleoid-associated proteins Fis and H-NS collaborate with fluctuations in the superhelicity of the DNA template to modify the gene expression profile of the bacterial cell outside and inside the host.
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