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Related Experiment Video

Updated: Jun 25, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Acantholytic anaplastic Paget's disease.

Narciss Mobini¹

¹Department of Pathology, University of Nevada School of Medicine, Las Vegas, NV, USA. mscons@aol.com

Journal of Cutaneous Pathology

|February 18, 2009

Summary

Anaplastic Paget's disease (PD) mimics Bowen's disease, posing a diagnostic challenge. Accurate diagnosis requires a high index of suspicion and comprehensive immunohistochemistry, especially for challenging breast skin lesions.

Area of Science:

Dermatopathology
Oncology

Background:

Classic Paget's disease (PD) is typically diagnosed via histopathology.
Anaplastic PD is a rare variant that presents diagnostic challenges.

Observation:

Two cases presented with scaly, erythematous nipple/areola plaques.
Initial biopsies mimicked Bowen's disease with acantholysis, lacking classic Paget's cells.
Immunohistochemistry showed negativity for mucin, GCDFP-15, and variable CEA, but strong CK7 positivity.

Findings:

Anaplastic PD histologically resembles Bowen's disease with superficial acantholysis.
Immunohistochemical profile includes mucin, CEA, and GCDFP-15 negativity with CK7 positivity.
Both cases ultimately revealed high-grade ductal carcinoma in situ.

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Last Updated: Jun 25, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Implications:

A high index of suspicion is crucial for diagnosing anaplastic PD.
Complete immunohistochemical panels are essential for evaluating Bowenoid neoplasms of breast skin.
Consider anaplastic PD in superficial shave biopsies with negative imaging and no palpable mass.