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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Home blood testing for celiac disease: recommendations for management

Mohsin Rashid1, J Decker Butzner, Ralph Warren

  • 1Dalhousie University, Department of Pediatrics, IWK Health Centre, 5850 University Ave, Halifax, NS B3K 6R8. mohsin.rashid@iwk.nshealth.ca

Canadian Family Physician Medecin De Famille Canadien
|February 18, 2009
PubMed

Insights

Home blood tests can screen for celiac disease, but positive results require a confirmatory small intestinal biopsy. Confirm diagnosis before starting a gluten-free diet.

Area of Science:

  • Gastroenterology
  • Immunology
  • Diagnostic Medicine

Background:

  • Increasing availability of self-administered home blood tests for celiac disease.
  • Need for clear management guidelines for positive home test results.

Purpose of the Study:

  • Provide recommendations for managing patients using home celiac disease blood tests.
  • Outline diagnostic pathways following positive self-test results.

Main Methods:

  • Systematic literature search of PubMed and Cochrane Database (1985-2008).
  • Inclusion of guidelines from American Gastroenterological Association and North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.
  • Focus on Level 1 evidence for diagnostic accuracy.

Main Results:

  • Home blood tests serve as a screening tool for celiac disease.
  • A small intestinal biopsy is the definitive confirmatory test for celiac disease.

Conclusions:

  • Positive blood test results for celiac disease necessitate further confirmation.
  • Endoscopic small intestinal biopsy is recommended to confirm celiac disease diagnosis prior to dietary changes.
Abstract

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