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Related Experiment Video

Updated: Jun 25, 2026

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

The resting brain: unconstrained yet reliable.

Zarrar Shehzad¹, A M Clare Kelly, Philip T Reiss

¹Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA.

Cerebral Cortex (New York, N.Y. : 1991)

|February 18, 2009

Summary

This summary is machine-generated.

Resting-state functional connectivity (fcMRI) shows reliable test-retest consistency across sessions. Reliability depends on correlation significance, valence, and network type, supporting its use in diverse populations.

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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

Area of Science:

Neuroimaging
Cognitive Neuroscience
Psychiatry

Background:

Resting-state functional magnetic resonance imaging (fMRI) is increasingly used to study functional connectivity (fcMRI).
Concerns exist regarding the reliability of
resting-state
fcMRI measures, particularly test-retest reliability.

Purpose of the Study:

To quantify the test-retest reliability and consistency of resting-state fcMRI measures.
To identify factors influencing the reliability of resting-state fcMRI.

Main Methods:

Resting-state fMRI scans from 26 participants at 3 different time points were analyzed.
Inter-session, intra-session, and multi-scan reliability were assessed using region-of-interest and voxel-wise analyses.
Hierarchical clustering was used to evaluate reproducibility.

Main Results:

Modest to high reliability was observed across connections, influenced by correlation significance, valence (positive > negative), and network membership (default mode > task positive).
Global connectivity patterns demonstrated high short- and long-term consistency.
Hierarchical clustering solutions were highly reproducible across participants and sessions.

Conclusions:

Resting-state fcMRI exhibits robust test-retest reliability, supporting its application in clinical and research settings.
Findings provide a foundation for the continued use of resting-state fcMRI in studying typical and atypical populations.