[13 parameters of coagulation and fibrinolysis--univariate pediatric normal values of hemostasis]

In order to establish age related univariate nonparametric tolerance regions in 74 healthy children and adolescents (age 2-18 years) undergoing elective surgery the following haemostatic parameters have been investigated: platelet count, von Willebrand factor, factor VIIIC, ristocetin-cofactor, antithrombin III, protein C fibrinogen, plasminogen, alpha-2-antiplasmin, C1-inactivator, alpha-1-antitrypsin, alpha-1-antichymotrypsin and alpha-macroglobulin. Compared to adult normal values medians of von Willebrand factor and protein C were lowered, alpha-2-antiplasmin, C1-inactivator and alpha-2-macroglobulin were elevated, whereas the medians of alpha-1-antitrypsin and alpha-1-antichymotrypsin reached the lower adult borderline. The other investigated parameters showed no difference to those of adults.