Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Single-incision robotic colorectal surgery with the da Vinci SP® surgical system: initial results of 50 cases.

Techniques in coloproctology·2023

Same author

Surgical management of pelvic organ prolapse.

Climacteric : the journal of the International Menopause Society·2018

Same author

MRI analysis of extra-capsular ganglia at the gastrocnemius origin and their association with osteoarthritis.

Clinical radiology·2018

Same author

Development of a new analgesic index using nasal photoplethysmography.

Anaesthesia·2018

Same author

A validation of dynamic causal modelling for 7T fMRI.

Journal of neuroscience methods·2018

Same author

Acceptability of HIV self-sampling kits (TINY vial) among people of black African ethnicity in the UK: a qualitative study.

BMC public health·2018

Same journal

Radioligand therapy for paediatric patients with solid tumours.

The British journal of radiology·2026

Same journal

Vertebral computed tomography attenuation to case-find low bone density in people undergoing lung cancer screening.

The British journal of radiology·2026

Same journal

Machine learning models using 18F-FDG PET/CT radiomics for RAS mutation prediction and prognostic stratification in colorectal cancer.

The British journal of radiology·2026

Same journal

Predictors of Relapse in Oligometastatic Prostate Patients Receiving Stereotactic Ablative Radiotherapy.

The British journal of radiology·2026

Same journal

An Evaluation of Radiotherapy and Response in the Management of Perivascular Epithelioid Cell Tumors.

The British journal of radiology·2026

Same journal

Ensuring radiology reporting quality across a national lung cancer screening programme.

The British journal of radiology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Animal Models of Depression - Chronic Despair Model (CDM)

Animal Models of Depression - Chronic Despair Model (CDM)

Published on: September 23, 2021

Specific hippocampal choline decrease in an animal model of depression.

S-T Hong¹, C-B Choi, C Park

¹High Field Magnetic Resonance Center, Max-Planck Institute for Biological Cybernetics, Tübingen, Germany.

The British Journal of Radiology

|February 18, 2009

Summary

This summary is machine-generated.

Depression in rats is linked to lower choline levels in the left hippocampus, mirroring human findings. This suggests hippocampal choline ratios could serve as biomarkers for depression.

More Related Videos

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

Related Experiment Videos

Last Updated: Jun 25, 2026

Animal Models of Depression - Chronic Despair Model (CDM)

Animal Models of Depression - Chronic Despair Model (CDM)

Published on: September 23, 2021

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

Area of Science:

Neuroscience
Biochemistry
Psychiatry

Background:

Previous proton magnetic resonance spectroscopy ((1)H-MRS) studies indicate reduced hippocampal choline signals in human depression.
The forced swimming test (FST) is a standard animal model for evaluating antidepressant efficacy.

Purpose of the Study:

To investigate changes in hippocampal choline levels in rats before and after the FST.
To determine if these changes correlate with depression-like behaviors.

Main Methods:

Utilized (1)H-MRS to acquire spectral data from the left and right hippocampi of rats.
Administered the FST to assess depression-related responses.
Analyzed choline/creatine (Cho/Cr) and choline/N-acetylaspartate (Cho/NAA) ratios.

Main Results:

A significant reduction in Cho/Cr (p = 0.037) and Cho/NAA (p = 0.048) ratios was observed in the left hippocampus post-FST.
No significant changes were detected in the right hippocampus.
The observed decrease in the left hippocampus mirrors findings in human depression patients.

Conclusions:

Decreased Cho/Cr and Cho/NAA ratios in the left hippocampus of rats after FST are analogous to depression in humans.
These specific hippocampal choline ratios may function as potential biomarkers for depression in animal models.