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Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
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Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders

Petra E Spies1, René J F Melis, Magnus J C Sjögren

  • 1Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Donders Centre for Neuroscience, Nijmegen, The Netherlands. p.spies@ger.umcn.nl

Journal of Alzheimer'S Disease : JAD
|February 18, 2009
PubMed
Summary

Cerebrospinal fluid (CSF) alpha-synuclein levels did not differ between dementia with Lewy bodies (DLB) patients and those with Alzheimer's disease, vascular dementia, or frontotemporal dementia. Therefore, CSF alpha-synuclein is not a reliable biomarker for distinguishing DLB from other dementia types.

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