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Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
07:27

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 29, 2010

Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork

Stephanie Brown1, Atsuko Niimi, Alan R Lehmann

  • 1Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK.

Cell Cycle (Georgetown, Tex.)
|February 18, 2009
PubMed

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Restarting Stalled Replication Forks02:37

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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