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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

One renegade cancer stem cell?

Tijana Borovski1, Louis Vermeulen, Martin R Sprick

  • 1Laboratory for Experimental Oncology and Radiobiology, LEXOR, CEMM, AMC UvA, Amsterdam, The Netherlands.

Cell Cycle (Georgetown, Tex.)
|February 18, 2009
PubMed
Summary

Single cancer stem cells (CSCs) can initiate new tumors and differentiate. This study shows that individual glioblastoma CSCs possess multilineage potential, but CSCs from the same tumor may vary in their differentiation capacity.

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Area of Science:

  • Oncology
  • Cancer Stem Cell Biology
  • Glioblastoma Research

Background:

  • Cancer stem cells (CSCs) are crucial for tumor initiation, self-renewal, and differentiation.
  • A key question is whether a single CSC can generate tumor heterogeneity or if multiple CSCs are required.

Purpose of the Study:

  • To investigate the multilineage differentiation potential of single glioblastoma CSCs.
  • To determine if CSCs from the same glioblastoma tumor exhibit uniform differentiation potential.

Main Methods:

  • Isolation and culture of single glioblastoma CSCs.
  • Assessment of differentiation capacity of individual CSCs into various tumor cell types.

Main Results:

  • Single glioblastoma CSCs demonstrate multilineage differentiation potential.
  • CSCs derived from the same tumor are not uniformly capable of differentiation.

Conclusions:

  • A single glioblastoma CSC can possess the capacity for multilineage differentiation.
  • Tumor heterogeneity may arise not only from distinct CSC populations but also from variations within individual CSCs' differentiation potential.