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Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Multidisciplinary Approach to Obesity Management: A Case Report
05:10

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Published on: May 30, 2025

Rationale for redefining obesity in Asians.

Serena Low1, Mien Chew Chin, Stefan Ma

  • 1Health Services Research and Evaluation Division, Ministry of Health, Singapore. serena_low@moh.gov.sg

Annals of the Academy of Medicine, Singapore
|February 18, 2009
PubMed
Summary

Research indicates that Asian populations may require lower Body Mass Index (BMI) cut-off points for obesity than international standards. Further studies are needed to confirm these BMI recommendations for public health interventions.

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Area of Science:

  • Public Health
  • Epidemiology
  • Metabolic Health

Background:

  • Extensive research has focused on defining appropriate Body Mass Index (BMI) cut-off points for overweight and obesity in Asian populations since the 2002 WHO Expert Consultation.
  • International BMI guidelines may not accurately reflect the health risks associated with varying weight categories in diverse ethnic groups.

Purpose of the Study:

  • To review existing literature on optimal BMI cut-off points for Asian populations.
  • To assess the evidence supporting lower BMI thresholds for obesity in Asians compared to international recommendations.

Main Methods:

  • A comprehensive literature review was conducted using databases such as PubMed, EMBASE, Cochrane Library, and Google.
  • Eighteen relevant articles were selected after examining reference lists of retrieved studies.

Main Results:

  • Thirteen studies identified BMI cut-off points for Asian populations lower than the World Health Organisation (WHO) international recommendations.
  • Many studies suggest a need for lower, population-specific BMI cut-offs for Asians due to higher cardiovascular risk factors at any given BMI level compared to Western populations.
  • Some studies aligned with the 2002 recommendations from the International Association for the Study of Obesity (IASO), International Obesity Task Force (IOTF), and WHO.

Conclusions:

  • Further research is required to evaluate BMI cut-off recommendations for Asian populations, particularly by examining all-cause mortality.
  • Developing country-specific and ethnic-specific BMI cut-off points for Asians is crucial.
  • Tailored BMI guidelines will aid in creating effective preventive interventions for obesity-related public health issues in Asian communities.