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Updated: Jun 25, 2026

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Helical-ribbon formation by a beta-amino acid modified amyloid beta-peptide fragment
Valeria Castelletto1, Ian W Hamley, Rohan A Hule
1Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK.
Abstract:
An addition to the family: The introduction of beta-amino acid residues into a modified amyloid beta peptide fragment resulted in well-defined helical nanoribbons (see cryo-TEM image) comprising beta strands mainly oriented perpendicular to the ribbon axis. The nanoribbons order into a flow-aligning nematic phase at higher concentration. The beta-strand nanoribbon structure is an addition to the known set of secondary structures adopted by beta-peptides.
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