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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Folding and Characterization of a Bio-responsive Robot from DNA Origami
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Icosahedral DNA nanocapsules by modular assembly.

Dhiraj Bhatia1, Shabana Mehtab, Ramya Krishnan

  • 1National Centre for Biological Sciences, TIFR, GKVK, Bellary Road, Bangalore, 560 065, India.

Angewandte Chemie (International Ed. in English)
|February 18, 2009
PubMed
Summary

DNA polyhedra self-assemble into nanocapsules for targeted delivery. Researchers encapsulated gold nanoparticles (GNPs) within complex icosahedral DNA cages, demonstrating their potential as nanocarriers.

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Area of Science:

  • Nanotechnology
  • Biochemistry
  • Materials Science

Background:

  • DNA self-assembly offers precise control over nanoscale structure formation.
  • DNA nanostructures are being explored for various applications, including drug delivery.

Purpose of the Study:

  • To investigate the potential of DNA polyhedra as nanocapsules for targeted delivery.
  • To demonstrate the encapsulation of entities within complex DNA-based platonic solids.

Main Methods:

  • Utilized stepwise molecular self-assembly to construct DNA polyhedra.
  • Formed complex icosahedral DNA structures through the amalgamation of discrete polyhedra.
  • Encapsulated gold nanoparticles (GNPs) from solution during the assembly process.

Main Results:

  • Successfully formed complex DNA polyhedra, specifically icosahedra.
  • Demonstrated the encapsulation of gold nanoparticles (GNPs) within the icosahedral DNA cages.
  • Visual confirmation of GNPs within icosahedral cages via transmission electron microscopy (TEM).

Conclusions:

  • DNA polyhedra can function as effective nanocapsules.
  • The self-assembly process allows for the targeted encapsulation of nanoparticles.
  • These DNA-based nanocapsules show promise for targeted delivery applications.