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Updated: Jun 25, 2026
Immunization of Alpacas (Lama pacos) with Protein Antigens and Production of Antigen-specific Single Domain Antibodies
Published on: January 26, 2019
Humoral response to an equine encephalitis vaccine in healthy alpacas
Daniela Bedenice1, Amy Bright, Douglas D Pedersen
1Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
Objective:
To determine humoral responses to an equine encephalitis vaccine in healthy alpacas.
Design:
Clinical trial.
Animals:
39 healthy alpacas on 1 farm and 86 healthy alpacas on a second farm.
Procedures:
All alpacas were given 3 doses IM of a bivalent, killed-virus equine encephalitis vaccine, with 4 weeks between doses. Eastern equine encephalitis (EEE) virus neutralizing antibody responses were determined with a plaque reduction neutralization assay every 14 days in alpacas on the first farm and 70 days after the first dose of vaccine on the second farm.
Results:
For alpacas on the first farm, geometric mean virus neutralizing antibody titer peaked 2 weeks after the third vaccine dose was given (ie, day 70). At this time, 29 of 38 (76%) animals were seropositive for antibodies against EEE virus, and percentage of animals
Conclusions And Clinical Relevance:
Results suggested that inoculation of alpacas with 3 doses of a bivalent, killed-virus equine encephalitis vaccine induced a humoral antibody response against EEE virus.
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