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Association between low bone mass and aortic valve sclerosis in Koreans
Han S Choi1, Yumie Rhee, Nam W Hur
1Department of Internal Medicine, University College of Medicine, Seoul, Korea.
Clinical Endocrinology
|February 19, 2009
Summary
Low bone mass is linked to aortic valve sclerosis in women, but not men. This suggests women with low bone density need evaluation for heart valve issues and related cardiovascular diseases.
Area of Science:
- Cardiology
- Endocrinology
- Gerontology
Background:
- Osteoporosis and cardiovascular disease share risk factors.
- Valvular calcification, specifically aortic valve sclerosis, is increasingly recognized.
- The relationship between low bone mass and aortic valve sclerosis requires further investigation.
Purpose of the Study:
- To investigate the association between low bone mass and aortic valve sclerosis.
- To analyze this relationship in Korean men and women separately.
Main Methods:
- Cross-sectional study of 211 men and 117 women.
- Bone mineral density (BMD) measured by dual-energy X-ray absorptiometry.
- Aortic valve sclerosis assessed via transthoracic echocardiography; analyzed using multivariate logistic regression.
Main Results:
- Aortic valve sclerosis present in 23.7% of men and 15.4% of women.
- Women with aortic valve sclerosis had significantly lower BMD T-scores.
- In women, BMD T-score and age were independent predictors of aortic valve sclerosis; a T-score < -1.5 increased risk.
Conclusions:
- Low bone mass is independently associated with aortic valve sclerosis risk in women, but not men.
- Women with low bone mass warrant screening for aortic valve sclerosis and associated cardiovascular conditions.
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