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Update on the treatment of chronic kidney disease-mineral and bone disorder

Jordi Bover1, Neus Farré, Enric Andrés

  • 1Fundació Puigvert and Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain. jbover@fundacio-puigvert.es

Journal of Renal Care
|February 19, 2009
PubMed

Insights

Chronic kidney disease-mineral bone disorder (CKD-MBD) management has evolved beyond parathyroid hormone (PTH) control. A multidisciplinary approach and new treatments aim to improve cardiovascular and survival outcomes in CKD patients.

Area of Science:

  • Nephrology
  • Endocrinology
  • Internal Medicine

Background:

  • Chronic kidney disease (CKD) is linked to significant morbidity and mortality.
  • Disturbances in mineral metabolism are major contributors to mortality in CKD patients.
  • CKD-mineral bone disorder (CKD-MBD) is a systemic condition involving bone, mineral, and vascular abnormalities.

Purpose of the Study:

  • To review the current therapeutic strategies for CKD-MBD.
  • To discuss the latest advancements in treatments for CKD-MBD.
  • To highlight the shift towards improved cardiovascular and survival outcomes in CKD-MBD management.

Main Methods:

  • Review of current literature on CKD-MBD treatments.
  • Analysis of new therapeutic agents including phosphate binders, vitamin D derivatives, and calcimimetics.
  • Emphasis on the role of a multidisciplinary approach in patient management.

Main Results:

  • Current treatments focus on managing CKD-MBD beyond just parathyroid hormone (PTH) control.
  • New therapeutic agents offer improved management options for mineral metabolism disturbances.
  • A multidisciplinary approach involving nurses, dieticians, and clinicians enhances patient outcomes.

Conclusions:

  • CKD-MBD requires a comprehensive management strategy.
  • Novel treatments and a multidisciplinary approach are crucial for improving cardiovascular and survival outcomes in CKD patients.
  • The focus has shifted from managing renal osteodystrophy to a broader CKD-MBD paradigm.

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