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Related Experiment Video

Updated: Jun 25, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

Multiple rapid swallowing: a complementary test during standard oesophageal manometry.

F Fornari¹, I Bravi, R Penagini

¹Center for Gastroenterological Research, Catholic University of Leuven, Leuven, Belgium.

Neurogastroenterology and Motility

|February 19, 2009

Summary

Multiple rapid swallowing (MRS) can reveal hidden esophageal motility disorders in patients with normal manometry. A normal MRS response in ineffective esophageal motility (IOM) may predict treatment success.

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Area of Science:

Gastroenterology
Neurogastroenterology
Esophageal Physiology

Background:

Standard esophageal manometry can miss subtle motility abnormalities.
Oesophageal symptoms often require further diagnostic evaluation beyond standard tests.

Purpose of the Study:

To assess the diagnostic utility of multiple rapid swallowing (MRS) in identifying esophageal motility dysfunctions.
To evaluate MRS in patients with normal manometry or ineffective esophageal motility (IOM).

Main Methods:

MRS protocol involved five rapid water swallows (2 mL each, 2-3s apart).
Evaluated 23 healthy subjects, 109 symptomatic patients with normal manometry, and 48 patients with IOM.
Assessed oesophageal body (OB) contractions and lower oesophageal sphincter (LOS) responses.

Main Results:

Healthy subjects showed complete OB inhibition and enhanced post-MRS contractions.
Nearly 70% of symptomatic patients with normal manometry exhibited abnormal MRS responses.
Approximately 50% of IOM patients normalized OB contractions after MRS.

Conclusions:

MRS is a valuable complementary tool for esophageal manometry, detecting abnormalities in up to two-thirds of patients with normal standard tests.
Abnormal MRS may explain symptoms in patients with initially normal manometry.
A normal MRS response in severe IOM could predict efficacy of prokinetic therapy.