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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Drug Delivery Systems: Different Types01:27

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

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Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
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Published on: March 3, 2020

Light-sensitive intelligent drug delivery systems.

Carmen Alvarez-Lorenzo1, Lev Bromberg, Angel Concheiro

  • 1Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain. carmen.alvarez.lorenzo@usc.es

Photochemistry and Photobiology
|February 19, 2009
PubMed
Summary
This summary is machine-generated.

Intelligent drug delivery systems (DDS) utilize light-responsive materials for controlled release. These advanced DDS offer precise, on-demand therapeutic delivery, enhancing treatment efficacy and patient outcomes.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmacology

Background:

  • Controlled drug release is crucial for effective disease management.
  • Intelligent materials responding to stimuli offer advanced therapeutic potential.
  • Light-responsive materials are gaining traction for targeted drug delivery.

Purpose of the Study:

  • To review mechanisms for developing light-sensitive drug delivery systems (DDS).
  • To analyze polymeric micelles, gels, liposomes, and nanocomposites for light-responsiveness.
  • To discuss the potential of light-sensitive carriers in intelligent DDS.

Main Methods:

  • Analysis of light-responsive mechanisms in various DDS formulations.
  • Review of polymeric, lipidic, and inorganic structures for drug release control.
  • Discussion of single-use vs. multi-switchable light-responsive DDS.

Main Results:

  • Light-responsive DDS can be engineered using diverse materials (polymeric, lipidic, inorganic).
  • These systems enable on-demand and pulsatile drug release.
  • Light triggers structural changes for controlled release of solutes and biomacromolecules.

Conclusions:

  • Light-sensitive carriers are promising components for intelligent DDS.
  • Precise control over drug release kinetics is achievable.
  • Potential for tailored therapies responding to physiological needs or external triggers.