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Updated: Jun 25, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
Successful use of inhaled nitric oxide to decrease intracranial pressure in a patient with severe traumatic brain
Thomas J Papadimos1, Azedine Medhkour, Sooraj Yermal
1Department of Anesthesiology, College of Medicine, University of Toledo, Toledo, OH 43614, USA. thomas.papadimos@utoledo.edu
Abstract:
Use of inhaled nitric oxide in humans with traumatic brain injury and acute respiratory distress syndrome has twice previously been reported to be beneficial. Here we report a third case. We propose that INO may decrease the inflammatory response in patients with increased intracranial pressure caused by traumatic brain injury accompanied by acute respiratory distress syndrome thereby contributing to improved outcomes.
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